Modelling intervention effects after cancer relapses

Relapses after resection for pulmonary tuberculosis.

Plasmodium vivax Malaria Relapses after Primaquine Prophylaxis

Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 12, No. 11, November 2006 1795 contacts with clandestine gold panners, mainly Brazilian illegal residents. This population, in which malaria incidence is almost impossible to evaluate, comes from Amapa State, where the incidence of malaria is increasing (5). In 2003, 60.9% of patients with malaria cases at Cayenne Hospital had a Brazilian na...

Loco-regional relapses from rectal cancer

Background Loco-regional relapses (LRRs) from rectal cancer still represent a major issue in colo-rectal surgery. With the introduction of Total Mesorectal Excision (TME), LRR incidence after curative resection for rectal cancer dramatically decreased from 20–40% of cases to 2–12%. Several factors are involved in predicting LRRs, the most important of these being Dukes stage. When no treatment ...

Early relapses after adjuvant chemotherapy suggests primary chemoresistance in diffuse gastric cancer

BACKGROUND Survival from gastric cancer remains poor, particularly in Western populations. Previous pre-clinical and subgroup analyses of clinical trials have suggested differing benefits from fluoropyrimidine-based chemotherapeutics for diffuse and intestinal gastric cancer. This analysis examines patterns of relapse with and without adjuvant chemotherapy after curative resection for gastric c...

Validation of death prediction after breast cancer relapses using joint models

BACKGROUND Cancer relapses may be useful to predict the risk of death. To take into account relapse information, the Landmark approach is popular. As an alternative, we propose the joint frailty model for a recurrent event and a terminal event to derive dynamic predictions of the risk of death. METHODS The proposed prediction settings can account for relapse history or not. In this work, pred...